Cart
sales@molnova.com
Home - Products - GPCR/G Protein - Chemokine Receptor - AF-399 42016530

AF-399 42016530

CAS No. 618864-56-5

AF-399 42016530( AF-399/42016530 )

Catalog No. M15341 CAS No. 618864-56-5

A potent CCR4 antagonist that blocked CCL22- and CCL17-mediated migration of human peripheral blood CD4+CD25+ Treg and Th2 cells ex-vivo and murine Tregs in-vivo.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
100MG Get Quote Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    AF-399 42016530
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent CCR4 antagonist that blocked CCL22- and CCL17-mediated migration of human peripheral blood CD4+CD25+ Treg and Th2 cells ex-vivo and murine Tregs in-vivo.
  • Description
    A potent CCR4 antagonist that blocked CCL22- and CCL17-mediated migration of human peripheral blood CD4+CD25+ Treg and Th2 cells ex-vivo and murine Tregs in-vivo; enhances DC-mediated human CD4(+) T cell proliferation in an in vitro immune response model and amplifies cellular and humoral immune responses in vivo in experimental models, induces antigen-specific CD8+ T cells and tumor immunity against self antigens in combination with vaccines.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    AF-399/42016530
  • Pathway
    GPCR/G Protein
  • Target
    Chemokine Receptor
  • Recptor
    Chemokine Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    618864-56-5
  • Formula Weight
    531.619
  • Molecular Formula
    C26H17N3O4S3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    4-(1-benzofuran-2-ylcarbonyl)-1-[5-(benzylsulfanyl)-1,3,4-thiadiazol-2-yl]-3-hydroxy-5-(2-thienyl)-1,5-dihydro-2H-pyrrol-2-one.

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Klein A, et al. Oncotarget. 2017 May 9;8(19):31079-31091. 2. Bayry J, et al. Proc Natl Acad Sci U S A. 2008 Jul 22;105(29):10221-6. 3. Pere H, et al. Blood. 2011 Nov 3;118(18):4853-62.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • GSK 163929

    A potent, selective CCR5 antagonist and HIV-1 entry inhibitor with pIC50 of 8.37 and 8.46 in HOS and PBL assays, respectively.

  • CCR2-RA-[R]

    A potent, selective, allosteric CCR2 antagonist with IC50 of 103 nM.

  • LY-2510924

    LY-2510924 (LY2510924)?is a potent and selective, cyclic peptide CXCR4 antagonist with IC50 of 0.079 nM.

Sign In Join Free